Immediate laser-induced hemostasis in anticoagulated rats subjected to oral soft tissue surgery: a double-blind study

Abstract Given the growing trend towards medical indications for continuous use of anticoagulants, the number of patients on these medications continues to rise. The management of patients on oral anticoagulants requiring oral surgical procedures has aroused much controversy. Changes in an anticoagulation regimen are associated with an increased risk of thromboembolism. However, it seems logical and advantageous for the patients' health if surgery could be performed without any change to the anticoagulation therapy. In dentistry, high-power lasers have been poorly explored in this field. The hemostatic properties of high-power lasers could be helpful during oral soft tissue surgeries in anticoagulated patients. The aim of this study was to compare bleeding time in anticoagulated rats after lingual frenectomy performed with a scalpel or diode laser with bleeding time in healthy animals. Twenty-four male Wistar rats were assigned to four groups (n = 6): (CS) Control-Scalpel Surgery; (AS) Anticoagulated-Scalpel Surgery; (CL) Control-Laser (diode laser 810 nm/1.5 W) Surgery; and (AL) Anticoagulated-Laser Surgery (diode laser 810 nm/1.5 W). Warfarin administration was used to induce anticoagulation. Blood was blotted every 30 seconds with filter paper until bleeding stopped to verify bleeding time. Two blinded researchers performed the surgeries and collected the bleeding time data. Diode laser surgery led to complete hemostasis in rats during and after lingual frenectomy. Zero bleeding was assessed during surgeries and after diode laser surgeries in anticoagulated rats. Laser-induced hemostasis offered an alternative solution to the controversial issue of intraoperative and postoperative bleeding control in patients on anticoagulation therapy.

[ effect of radioactive lantern mantle powder and bentonite-zeoloite minerals on the volume of blood loss, bleeding and clotting time]

Over the past decade the US army has widely studied new technologies for stopping sever hemorrhages and has introduced an effective Zeolite based hemostatic agent. On the other hand, Mortazavi and his colleagues previously reported the bio-stimulatory effects of the topical application of radioactive lantern mantle powder on wound healing. Their subsequent studies showed significant changes in some histological parameters concerning healing. In this light, here the bio-stimulatory effect of burned radioactive lantern mantles powder as well as two minerals; bentonite and zeolite arepresented. This experimental study was conducted in the center for radiological studies, Shiraz university of Medical Sciences in 2008. Fifty male Wistar rats were divided randomly into 5 groups of 10 animals each. Following anesthesia, animals' tails were cut at a thickness of 5 mm by using a surgical scissor. No intervention was made on the animals of the 1[st] group. The 2[nd] group to 4[th] group received topical non-radioactive lantern mantle powder, radioactive lantern mantle powder, Bentonite mineral or a mixture of Bentonite-Zeoliteat minerals respectively. After treatment with above mentioned agents, the volume of blood loss was measured using a scaled test-tube. The bleeding time and clotting time were also measured using a chronometer. SPSS software was used for statistical analysis. ANOVA was used for comparing the means of each parameter in the 5 groups. The volume of blood loss, bleeding and clotting times in control animals were 4.39 +/- 1.92 cc, 112.10 +/- 39.60 sec and 94.9 +/- 54.26 sec, respectively. In the 5[th] group in which the animals were treated with a mixture of Bentonite-Zeoliteat minerals, the volume of blood loss, bleeding and clotting times were 1.31 +/- 0.60 cc, 34.50 +/- 4.65 sec and 24.2 +/- 4.61 sec, respectively. This is the 1[st] investigation that studied the alterations of bleeding and clotting times following the use of lantern mantle powder as well as bentonite or the mixture of bentonite-zeolite minerals. The results obtained in this study clearly show the significant effect of the volume of blood loss as well as the bleeding time following the topical use of the mixture of bentonite-zeolite minerals. The radioactive and non-radioactive lantern mantle and the bentonite mineral alone had considerable effects but overally the magnitude of the effect was less than that of the mixture of bentonite-zeolite minerals

Tratamento ambulatorial de hemorroidas: estudo prospectivo randomizado / Ambulatory treatment of hemorrhoids: a random trial

Duzentos e vinte e oito pacientes portadores de hemorroidas internas de segundo grau foram, aleatoriamente, distribuidos em tres grupos denominados, respectivamente de A,B, e C. Cada grupo foi submetido a ligadura elastica, os do grupo B a crioterapia e os grupo C ao infravermelho. Os resultados obtidos foram analisados e comparados com a finalidade de avaliaçao terapeutica. Todos os metodos foram considerados eficazes no tratamento das hemorroidas internas de segundo grau, salientando-se que a ligadura elastica foi o metodo menos doloroso de utilizaçao e que a crioterapia foi o metodo que menor indice de dor ofereceu no pos-tratamento, sendo o mais demorado para ser aplicado, e que o infravermelho foi o de melhor resultado quanto a desapariçao do sangramento, sendo o que apresentou complicaçoes de maior gravidade.